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[切尔诺贝利核电站事故发生四年后,在事故发生地30公里范围内工作的人员的临床免疫特征]

[Clinico-immunological characteristics of people who worked within the 30-kilometer zone of the accident at the Chernobyl Atomic Power Plant 4 years after the accident].

作者信息

Oradovskaia I V, Ruzybakiev R M, Prokopenko V D, Dmitriev A L, Zakharov G A, Androsov V N, Podobin N N, Mirkamalova L I, Askarova L I, Sevast'ianova E V

出版信息

Radiats Biol Radioecol. 1994 Jul-Oct;34(4-5):611-9.

PMID:7951892
Abstract

Clinical examination with immune status assessment of more than 300 healthy persons, who worked in 30-km Chernobyl NPP zone four years after the accident was carried out. The clinical characters of immune deficiency were detected in 6.67% of examined persons and appeared as repeated respiratory diseases. Significant increase in mean level of leukocytes and lymphocytes was revealed. Activation of T-helper link of cell immunity was determined by increase of CD4+ cells in 35.2% of examined persons, that were lower than in people who took part in Chernobyl accident amelioration in 1986. Decrease in content of T-cells and B-cells was observed in 1/4 and 3/4 of persons correspondingly by rosette assays. No changes in serum immunoglobulins level was observed.

摘要

对事故发生四年后在切尔诺贝利核电站30公里区域工作的300多名健康人员进行了临床检查及免疫状态评估。在6.67%的受检人员中检测到免疫缺陷的临床特征,表现为反复呼吸道疾病。白细胞和淋巴细胞平均水平显著升高。通过检测发现,35.2%的受检人员CD4 +细胞增加,表明细胞免疫的辅助性T细胞环节被激活,这些人员的CD4 +细胞水平低于1986年参与切尔诺贝利事故善后工作的人员。通过玫瑰花环试验分别观察到,四分之一和四分之三的人员T细胞和B细胞含量下降。血清免疫球蛋白水平未观察到变化。

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