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[切尔诺贝利原子能发电站事故30公里控制区内人员T淋巴细胞亚群、α1胸腺素含量及胸腺上皮细胞自身抗体的比较评估]

[A comparative evaluation of the content of T-lymphocyte subpopulations, alpha 1-thymosin and autoantibodies to epithelial thymic cells in the personnel in the 30-kilometer control zone of the accident at the Chernobyl Atomic Electric Power Station].

作者信息

Titova L D, Oradovskaia I V, Sharova N I, Iarilin A A

出版信息

Radiats Biol Radioecol. 1996 Jul-Aug;36(4):601-9.

PMID:8925033
Abstract

A significant decrease in mean number of CD5+, CD8(+)-lymphocytes in persons, who worked in 30-km zone of Chernobyl nuclear power station was revealed. A significant increase in percent of CD5+, CD4(+)-cell percents was observed in workers, who worked for 1,2-2,5 years in zone, but absolute number, were decreased comparing a control and data received in people, who have just arrived to work in 30-km zone. The positive correlation exists between the percent of lymphocytes and years of service in 30-km zone. The lower level of alpha 1-thymosine was revealed in serum of the persons, who worked in zone for 4.5-5 years than data received in people, who worked for 0.5 year. Increase level of serum autoantibodies reacting with thymic epithelial cell was detected in men, who worked in zone for 3-3.5 years. In persons, who worked more 5 years and have just arrived in zone identical data were received.

摘要

在切尔诺贝利核电站30公里区域工作的人员中,发现CD5⁺、CD8⁺淋巴细胞的平均数量显著减少。在该区域工作1.2至2.5年的工人中,观察到CD5⁺、CD4⁺细胞百分比显著增加,但与对照组以及刚到30公里区域工作的人员的数据相比,其绝对数量减少。淋巴细胞百分比与在30公里区域的工作年限之间存在正相关。在该区域工作4.5至5年的人员血清中,α1胸腺素水平低于工作0.5年的人员。在该区域工作3至3.5年的男性中,检测到与胸腺上皮细胞反应的血清自身抗体水平升高。在工作超过5年以及刚到该区域的人员中,得到了相同的数据。

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