Van Belle K, De koster V, Sarre S, Ebinger G, Michotte Y
Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussels, Belgium.
J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):149-54. doi: 10.1016/0378-4347(94)80081-2.
An isocratic narrow-bore high-performance liquid chromatographic assay with UV detection is described for the detection of oxcarbazepine and its major metabolite, 10,11-dihydro-10-hydroxycarbamazepine, using carbamazepine as the internal standard. This method is sufficiently sensitive to allow quantification of oxcarbazepine and its metabolite in rat brain, liver and blood microdialysates.
描述了一种采用紫外检测的等度窄孔高效液相色谱法，以卡马西平作为内标物，用于检测奥卡西平及其主要代谢物10,11-二氢-10-羟基卡马西平。该方法灵敏度足够高，能够对大鼠脑、肝和血液微透析液中的奥卡西平和其代谢物进行定量分析。
