旧世界猴的自发性和实验性甲型肝炎
Spontaneous and experimental hepatitis A in Old World monkeys.
作者信息
Shevtsova Z V, Lapin B A, Doroshenko N V, Krilova R I, Korzaja L I, Lomovskaya I B, Dzhelieva Z N, Zairov G K, Stakhanova V M, Belova E G
机构信息
Institute of Experimental Pathology and Therapy, USSR Academy of Medical Sciences, Sukhumi, Moscow.
出版信息
J Med Primatol. 1988;17(4):177-94.
Virologic, serologic, biochemical, and morphological data characterizing spontaneous hepatitis A (HA) in cynomolgus macaques (Macaca fascicularis) and green monkeys (Cercopithecus aethiops) are reported. Experimental HA was induced in macaques as a result of infection with human hepatitis A virus (HAV-h). Disease similar to human HA was induced in cynomolgus macaques by HAV isolates from spontaneously sick rhesus (M. mulatta) and green monkeys. This experimental model of HA in macaques can be used for vaccine and anti-viral preparation testing.
报告了食蟹猕猴（Macaca fascicularis）和绿猴（Cercopithecus aethiops）中自发性甲型肝炎（HA）的病毒学、血清学、生物化学和形态学数据。实验性甲型肝炎是由于感染人甲型肝炎病毒（HAV-h）在猕猴中诱发的。来自自发性患病恒河猴（M. mulatta）和绿猴的甲型肝炎病毒分离株在食蟹猕猴中诱发了与人类甲型肝炎相似的疾病。猕猴中这种甲型肝炎的实验模型可用于疫苗和抗病毒制剂测试。
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