Daly J W, Shi D, Wong V, Nikodijevic O
Laboratory of Bioorganic Chemistry, National Institutes of Health, Bethesda, MD 20892.
Brain Res. 1994 Jul 4;650(1):153-6. doi: 10.1016/0006-8993(94)90219-4.
Chronic ingestion of 5% ethanol had no significant effect on open field locomotor of NIH Swiss strain male mice, nor were the depressant effects of a non-selective adenosine receptor agonist, NECA, or the stimulant effects of a non-selective antagonist, caffeine significantly altered. The density of cerebral cortical A1-adenosine receptors and of nitrendipine binding sites on calcium channels were significantly increased after chronic ethanol, while the density of striatal A2a-adenosine receptors were unchanged. The locomotor stimulant effects of ethanol (2.5 g/kg) were slightly decreased after chronic ethanol, but were markedly reduced in mice after chronic caffeine ingestion. The results suggest some involvement of adenosine systems in the effects of ethanol.
长期摄入5%的乙醇对NIH瑞士品系雄性小鼠的旷场运动能力没有显著影响，非选择性腺苷受体激动剂NECA的抑制作用或非选择性拮抗剂咖啡因的兴奋作用也没有明显改变。长期摄入乙醇后，大脑皮质A1-腺苷受体的密度以及钙通道上尼群地平结合位点的密度显著增加，而纹状体A2a-腺苷受体的密度未发生变化。长期摄入乙醇后，乙醇（2.5克/千克）的运动兴奋作用略有降低，但在长期摄入咖啡因的小鼠中则显著降低。结果表明腺苷系统在乙醇的作用中存在一定参与。
