N-甲基-D-天冬氨酸（NMDA）与血清素（5-羟色胺，5-HT）在乙醇耐受性方面的相互作用。

Interaction between N-methyl-D-aspartate (NMDA) and serotonin (5-HT) on ethanol tolerance.

作者信息

Khanna J M, Kalant H, Chau A, Shah G, Morato G S

机构信息

Department of Pharmacology, University of Toronto, Canada.

出版信息

Brain Res Bull. 1994;35(1):31-5. doi: 10.1016/0361-9230(94)90212-7.

DOI:10.1016/0361-9230(94)90212-7

PMID:7953754

Abstract

Earlier work from this laboratory had shown that 5-HT is involved in the development of tolerance to ethanol, and that enhancement of 5-HT levels by L-tryptophan accelerated tolerance development. To explore the possibility that NMDA receptors are involved in the 5-HT effect on tolerance, we examined the effect of a noncompetitive N-methyl-D-aspartate (NMDA) antagonist [(+)MK-801] on the ability of L-tryptophan to enhance tolerance to the effect of ethanol on tilt-plane test performance by the rat. L-Tryptophan treatment resulted in the development of rapid tolerance to a dose of ethanol that failed to produce such tolerance by itself. However, prior administration of (+)MK-801 blocked the L-tryptophan effect on rapid tolerance development, in a dose-dependent manner. These results suggest that NMDA receptors are involved in the 5-HT enhancement of ethanol tolerance.

摘要

该实验室早期的研究表明，5-羟色胺（5-HT）参与了对乙醇耐受性的形成，并且L-色氨酸提高5-HT水平会加速耐受性的形成。为了探究N-甲基-D-天冬氨酸（NMDA）受体是否参与5-HT对耐受性的影响，我们研究了非竞争性N-甲基-D-天冬氨酸（NMDA）拮抗剂[(+)MK-801]对L-色氨酸增强大鼠对乙醇在倾斜平面试验表现影响的耐受性能力的作用。L-色氨酸处理导致对一定剂量乙醇快速产生耐受性，而该剂量乙醇本身不会产生这种耐受性。然而，预先给予(+)MK-801会以剂量依赖的方式阻断L-色氨酸对快速耐受性形成的作用。这些结果表明，NMDA受体参与了5-HT对乙醇耐受性的增强作用。