N-甲基-D-天冬氨酸拮抗剂对苯二氮䓬类药物快速耐受性的影响。

Effect of NMDA antagonists on rapid tolerance to benzodiazepines.

作者信息

Khanna J M, Chau A, Shah G

机构信息

Department of Pharmacology, University of Toronto, Canada.

出版信息

Brain Res Bull. 1997;42(2):99-103. doi: 10.1016/s0361-9230(96)00219-5.

DOI:10.1016/s0361-9230(96)00219-5

PMID:8971413

Abstract

We have reexamined the effect of NMDA antagonists [(+)MK-801 and ketamine] on rapid tolerance to chlordiazepoxide. (+)MK-801 and ketamine blocked the development of rapid tolerance to chlordiazepoxide, but this effect was dependent on the dose ratio of the NMDA antagonist to that of the benzodiazepine used to produce rapid tolerance. Furthermore, NMDA antagonists blocked both learned and unlearned tolerance to chlordiazepoxide. It appears that in addition to impairment of memory and learning, NMDA antagonists may also influence some other mechanism involved in the production of drug-tolerance.

摘要

我们重新研究了N-甲基-D-天冬氨酸（NMDA）拮抗剂[（+）MK-801和氯胺酮]对氯氮卓快速耐受性的影响。（+）MK-801和氯胺酮可阻断氯氮卓快速耐受性的形成，但这种作用取决于NMDA拮抗剂与用于产生快速耐受性的苯二氮卓类药物的剂量比。此外，NMDA拮抗剂可阻断对氯氮卓的习得性和非习得性耐受性。看来，除了损害记忆和学习外，NMDA拮抗剂还可能影响参与药物耐受性产生的其他一些机制。