关于十烃季铵和琥珀酰胆碱对红细胞膜稳定作用的简短通讯
Short communication on erythrocyte membrane stabilization by decamethonium and succinylcholine.
作者信息
Effraim K D, Ahmad K
机构信息
Department of Pharmacology, College of Medical Sciences, University of Maiduguri, Borno State, Nigeria.
出版信息
Cent Afr J Med. 1994 May;40(5):134-6.
PMID:7954726
Abstract
The effects of decamethonium and succinylcholine on hypotonic haemolysis of erythrocytes were studied. These drugs at concentrations of 5 x 10(-8) M to 10(-4) M caused a dose dependent inhibition of haemolysis of erythrocytes in 0.45 pc NaCl but lysis occurred when the drug concentrations were increased to 10(-3) M. These results indicate that decamethonium and succinylcholine may have a membrane stabilization-lysis effect on erythrocytes.
摘要
研究了十烃季铵和琥珀酰胆碱对红细胞低渗溶血的影响。这些药物浓度在5×10⁻⁸M至10⁻⁴M时，对0.45%氯化钠溶液中的红细胞溶血有剂量依赖性抑制作用，但当药物浓度增加到10⁻³M时会发生溶血。这些结果表明，十烃季铵和琥珀酰胆碱可能对红细胞具有膜稳定-溶解作用。
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