van Eerdenburg F J, Rakic P
Section of Neurobiology, Yale School of Medicine, New Haven, CT 06510.
Brain Res Dev Brain Res. 1994 Jun 17;79(2):290-6. doi: 10.1016/0165-3806(94)90134-1.
The time of formation of neurons of the various nuclei of the anterior hypothalamus of the rhesus monkey has been determined using [3H]thymidine autoradiography. Plotting of heavily radiolabeled nuclei indicate that in the macaque monkey neurons of the hypothalamus are generated during three weeks, between the 27th and 48th day of the 165 gestational period of this species. The individual nuclei generally display two waves of neuronal generation. Furthermore, a caudolateral to rostromedial gradient of neurogenesis has been observed in the supraoptic nucleus and a dorsal to ventral gradient in the paraventricular nucleus. Thus, neurons of the primate hypothalamus are generated at a much earlier stage of gestation and their generation lasts about three times longer than in rodents. However, most of the basic neurogenetic gradients are remarkably similar, in spite of species specific differences in cytoarchitecture of specific nuclei.
利用[3H]胸腺嘧啶核苷放射自显影技术确定了恒河猴下丘脑前部各核团神经元的形成时间。对放射性标记较重的核团进行绘图显示，在猕猴中，下丘脑神经元在该物种165天妊娠期的第27天至第48天这三周内生成。各个核团通常呈现出两波神经元生成。此外，在视上核中观察到从尾外侧到吻内侧的神经发生梯度，在室旁核中观察到从背侧到腹侧的梯度。因此，灵长类动物下丘脑的神经元在妊娠的更早阶段生成，其生成持续时间比啮齿动物长约三倍。然而，尽管特定核团的细胞结构存在物种特异性差异，但大多数基本的神经发生梯度非常相似。
