Degani H, Furman E, Fields S
Department of Chemical Physics, Weismann Institute of Science, Rehovot, Israel.
Clin Chim Acta. 1994 Jul;228(1):19-33. doi: 10.1016/0009-8981(94)90054-x.
Magnetic resonance imaging at high spatial resolution, dynamic-contrast enhanced imaging, and localized 31P magnetic resonance spectroscopy were applied to monitor in vivo growth and tamoxifen treatment of MCF7 human breast tumors implanted in athymic mice. Correlation of the imaging data with histological findings demonstrated significant differences between viable carcinoma, fibrous, and necrotic regions on T2 weighted images. At an early stage after tamoxifen treatment rapid necrosis preceded tumor regression suggesting tamoxifen inhibition of angiogenesis. The necrosis was followed by growth of reperative fibrous tissue at the boundary of the viable cancer cells and the necrotic regions. The dynamic of contrast enhancement after tamoxifen treatment revealed high permeability of microvessels at this boundary cord. In parallel to the induction of the repair process the tumor energy profile changed, showing a significant increase in the ratio of ATP to inorganic phosphate. Initial attempts to use MRI for evaluating the response of breast cancer patients to treatment are also described.
应用高空间分辨率磁共振成像、动态对比增强成像和局部31P磁共振波谱法，监测植入无胸腺小鼠体内的MCF7人乳腺肿瘤的体内生长情况及他莫昔芬治疗效果。成像数据与组织学结果的相关性表明，在T2加权图像上，存活癌、纤维组织和坏死区域之间存在显著差异。他莫昔芬治疗后的早期阶段，快速坏死先于肿瘤消退，提示他莫昔芬抑制血管生成。坏死之后，在存活癌细胞与坏死区域的边界处有修复性纤维组织生长。他莫昔芬治疗后对比增强的动态变化显示，该边界索处微血管具有高通透性。与修复过程的诱导同时，肿瘤能量谱发生变化，显示ATP与无机磷酸盐的比率显著增加。还介绍了利用MRI评估乳腺癌患者治疗反应的初步尝试。
