Wakelin S H, James M P
Department of Dermatology, Royal Berkshire Hospital, Reading, Berkshire, UK.
Clin Exp Dermatol. 1994 Jul;19(4):332-4. doi: 10.1111/j.1365-2230.1994.tb01208.x.
A 55-year-old woman is described with a short history of generalized lichen sclerosus et atrophicus in whom extensive blistering and ulceration occurred. The disease was confined to extragenital sites at presentation, with no clinical evidence of mucosal involvement. The degree of blistering, rapid evolution and widespread involvement of non-genital skin in this case are uncommon features. There was evidence of improvement following treatment with hydroxychloroquine. We suggest that this drug may be of therapeutic benefit in cutaneous lichen sclerosus.
一名55岁女性，患有泛发性硬化萎缩性苔藓，病程较短，出现广泛水疱和溃疡。该疾病初发时局限于生殖器外部位，无黏膜受累的临床证据。此病例中水疱程度、快速进展以及非生殖器皮肤的广泛累及均为不常见特征。使用羟氯喹治疗后有改善迹象。我们认为该药可能对皮肤性硬化萎缩性苔藓有治疗益处。
