Zaki I, Scerri L, Nelson H
Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham, UK.
Clin Exp Dermatol. 1994 Sep;19(5):388-90. doi: 10.1111/j.1365-2230.1994.tb02688.x.
We report a 22-year-old female with a 2-year history of increasingly numerous well-circumscribed, asymptomatic skin lesions. The clinical and histological features were consistent with anetoderma and investigations failed to reveal any associated underlying disorders. Electron microscopy of abnormal skin showed phagocytosis of elastic fibres by macrophages. Although the aetiology of primary anetoderma remains unknown, this finding suggests that phagocytic destruction of elastic fibres plays a major role in its pathogenesis.
我们报告了一名22岁女性，有2年病史，皮肤出现越来越多边界清晰、无症状的皮损。临床和组织学特征与皮肤松弛症相符，各项检查均未发现任何相关的潜在疾病。对异常皮肤进行电子显微镜检查显示巨噬细胞对弹性纤维的吞噬作用。虽然原发性皮肤松弛症的病因尚不清楚，但这一发现表明弹性纤维的吞噬性破坏在其发病机制中起主要作用。
