Ling S H, Ye R G, Dong X Q
Renal Research Institute, Sun Yet-sen University of Medical Sciences, Guangzhou.
Zhonghua Nei Ke Za Zhi. 1994 Apr;33(4):255-8.
For differentiation of glomerular from urological hematuria more accurately, a new morphological classification of urinary erythrocytes was studied in 74 cases of glomerular and 58 cases of urological hematuria. For each urine sample, 100 urinary erythrocytes were observed with phase-contrast microscopy and classified into 5 "glomerular" shapes (G1-G5), 5 "urological" shapes (N1-N5) and an unclassified shape. The result was that occurrence of G1, G2, G3, G4, G5 or unclassified shape group appeared significantly (P < 0.01) higher in glomerular diseases than in urological diseases, and among them G1 was the most specific shape for glomerular hematuria. Using percentage of sigma G (G1 + G2 + G3 + G4 + G5) and setting the cut-off at 20%, the sensitivity and specificity for the diagnosis of glomerular diseases were 95.9%. When percentage of G1 (doughnut-like cell with one or more blebs) was used at a cut-off of 1%, sensitivity and specificity were 75.7% and 96.5% respectively. These results were more satisfactory as compared with those in most of the previous reports. Moreover, this new classification is more objective, accurate and clear.
为了更准确地区分肾小球性血尿和泌尿外科血尿，对74例肾小球性血尿患者和58例泌尿外科血尿患者的尿红细胞进行了新的形态学分类研究。对每份尿液样本，用相差显微镜观察100个尿红细胞，并将其分为5种“肾小球性”形态（G1 - G5）、5种“泌尿外科性”形态（N1 - N5）和一种未分类形态。结果显示，肾小球疾病中G1、G2、G3、G4、G5或未分类形态组的出现率显著高于泌尿外科疾病（P < 0.01），其中G1是肾小球性血尿最具特异性的形态。使用σG（G1 + G2 + G3 + G4 + G5）的百分比并将临界值设定为20%时，诊断肾小球疾病的敏感性和特异性为95.9%。当使用G1（有一个或多个小泡的环形细胞）的百分比并将临界值设定为1%时，敏感性和特异性分别为75.7%和96.5%。与大多数先前报告的结果相比，这些结果更令人满意。此外，这种新分类更客观、准确和清晰。
