McGrouther D A
Division of Plastic Surgery, University College London, Rayne Institute, UK.
Eye (Lond). 1994;8 ( Pt 2):200-3. doi: 10.1038/eye.1994.46.
Further attempts to achieve a clinical distinction between hypertrophic and keloid scars seem pointless. Research in recent years has shifted from the extracellular components towards the cells themselves. Much more work needs to be done to characterise the activities of the various cell lines and the mechanisms of their control. A key question is whether the cells are due to a different subpopulation of fibroblasts or whether they are normal wound-healing cells acting under some chemical or physical influence. Ultimately, most hypertrophic and keloid scars become flat and pale, although the time sequence is very variable and there is little understanding of the process of scar maturation. Meanwhile, the problem remains as a significant cause of human suffering deserving further investment of time and resources.
进一步尝试在肥厚性瘢痕和瘢痕疙瘩之间实现临床区分似乎毫无意义。近年来的研究已从细胞外成分转向细胞本身。要表征各种细胞系的活性及其控制机制，还需要做更多工作。一个关键问题是，这些细胞是源自不同亚群的成纤维细胞，还是正常的伤口愈合细胞在某种化学或物理影响下起作用。最终，大多数肥厚性瘢痕和瘢痕疙瘩会变平、变淡，尽管时间顺序差异很大，而且对瘢痕成熟过程了解甚少。与此同时，这个问题仍然是人类痛苦的一个重要原因，值得进一步投入时间和资源。
