Nam B H, Rha K S, Yoo J Y, Park C I
Department of Otolaryngology, College of Medicine, Chungnam National University, Daejeon, South Korea.
Head Neck. 1994 Sep-Oct;16(5):457-9. doi: 10.1002/hed.2880160512.
Plasma cell granuloma is a rare benign lesion which is found most frequently in the lungs, and a few cases have been described in the head and neck. In the middle ear and mastoid, a case of plasma cell granuloma was reported by Benton et al.
A 24-year-old woman was seen with a 7-month history of otalgia and decreased hearing. A computed tomographic (CT) scan showed a soft tissue mass occupying most of the mastoid bone. The mass and the contiguous dura were enhanced homogeneously on magnetic resonance imaging (MRI) scan. Microscopic examination showed plasma cell aggregates mixed with other inflammatory cells and Russell's bodies in a fibrous stroma. Immunoperoxidase studies revealed intracytoplasmic kappa and lambda light chains, and the lesion was confirmed as non-neoplastic and of polyclonal origin (ie, plasma cell granuloma). The patient was treated with conservative surgical excision (a canal-down mastoidectomy) and postoperative radiotherapy (5,040 cGy in 28 fractions) and remains free of disease 1 year after treatment.
A case of plasma cell granuloma is reported, and we believe this is the second case report of plasma cell granuloma affecting the temporal bone.
浆细胞性肉芽肿是一种罕见的良性病变，最常见于肺部，头颈部仅有少数病例报道。在中耳和乳突，Benton等人报道过1例浆细胞性肉芽肿。
一名24岁女性，有7个月耳痛及听力下降病史。计算机断层扫描（CT）显示软组织肿块占据大部分乳突骨。磁共振成像（MRI）扫描显示肿块及相邻硬脑膜均匀强化。显微镜检查显示浆细胞聚集，与其他炎性细胞及纤维基质中的拉塞尔小体混合存在。免疫过氧化物酶研究显示胞浆内κ和λ轻链，病变被证实为非肿瘤性且为多克隆起源（即浆细胞性肉芽肿）。患者接受了保守性手术切除（经耳道乳突根治术）及术后放疗（28次分割，共5040厘戈瑞），治疗1年后仍无疾病复发。
报道了1例浆细胞性肉芽肿病例，我们认为这是第二例累及颞骨的浆细胞性肉芽肿病例报告。
