Kotzin B L
National Jewish Center for Immunology and Respiratory Medicine, Denver.
Hosp Pract (Off Ed). 1994 Nov 15;29(11):59-63, 68-70. doi: 10.1080/21548331.1994.11443108.
Because superantigens bind to extremely large numbers of T cells, they are useful for investigating the immune system. Moreover, they appear to have diverse pathologic roles. They may be responsible for massive cytokine release in toxic shock, activate self-reactive T cells in Kawasaki disease and rheumatoid arthritis, and participate in immune tolerance and deficiency.
由于超抗原能与大量T细胞结合，因此它们在研究免疫系统方面很有用。此外，它们似乎具有多种病理作用。它们可能是中毒性休克中大量细胞因子释放的原因，在川崎病和类风湿性关节炎中激活自身反应性T细胞，并参与免疫耐受和免疫缺陷。
