Reubinoff B E, Simon A, Friedler S, Schenker J G, Lewin A
Department of Obstetrics and Gynaecology, Hebrew University, Hadassah Medical Centre, Jerusalem, Israel.
Hum Reprod. 1994 Jun;9(6):1143-5. doi: 10.1093/oxfordjournals.humrep.a138647.
Impaired reproduction is common among patients afflicted with beta-thalassaemia major and is attributed mainly to the deposition of haemosiderin in the pituitary gland and ovaries. In-vitro fertilization (IVF)--embryo transfer cycles including ovum donation cycles are described for the first time in a patient with beta-thalassaemia major. The patient's oocytes were not fertilized by the husband's sperm in repeated IVF attempts. However, when donated oocytes were used, in two consecutive cycles, most were fertilized by the husband, yielding pregnancies after each embryo transfer. It is suggested that in this case of beta-thalassaemia major, impaired oocyte function contributed to infertility. However, a possible association between thalassaemia major and defective oocytes should be tested on a basis of additional IVF-embryo transfer cycles in these patients.
重度β地中海贫血患者常出现生殖功能受损，这主要归因于含铁血黄素在垂体和卵巢的沉积。本文首次描述了一位重度β地中海贫血患者的体外受精（IVF）——胚胎移植周期，包括卵子捐赠周期。在多次IVF尝试中，患者的卵母细胞均未被其丈夫的精子受精。然而，当使用捐赠的卵母细胞时，在连续两个周期中，大多数卵母细胞被其丈夫的精子受精，每次胚胎移植后均成功妊娠。提示在该重度β地中海贫血病例中，卵母细胞功能受损导致了不孕。然而，重度地中海贫血与卵母细胞缺陷之间的可能关联应在这些患者的额外IVF-胚胎移植周期基础上进行检验。
