Ezra Y, Simon A, Laufer N
Department of Obstetrics and Gynecology, Hadassah University Hospital, Ein-Kerem, Jerusalem, Israel.
Fertil Steril. 1992 Jul;58(1):24-7. doi: 10.1016/s0015-0282(16)55131-0.
To define a new category of unexplained infertility and its potential treatment.
Normal infertile couples underwent prospectively, cross-fertilization attempts in which the wife's oocytes were inseminated by the husband and donor semen. After recurrent failure of fertilization, cross insemination of donor oocytes was attempted with the husband sperm.
In vitro fertilization unit at a teaching hospital.
Three couples who were diagnosed as suffering of unexplained infertility and treated by in vitro fertilization (IVF).
The female partner of these couples produced morphologically normal oocytes that were demonstrated to be functionally defective and failed to fertilize in vitro with both husband and donor sperm. Donated oocytes inseminated by the husband's sperm were fertilized in all patients, demonstrating the normal fertilizing ability of the husbands' semen. One patient conceived and delivered after an oocyte donation.
Conclusive diagnosis of defective oocytes as a cause of infertility may be made only after IVF and oocyte donation.
定义一类新的不明原因不孕症及其潜在治疗方法。
正常不孕夫妇前瞻性地进行交叉受精尝试，即妻子的卵母细胞用丈夫的精液和供体精液进行授精。在反复受精失败后，尝试用丈夫的精子对供体卵母细胞进行交叉授精。
一家教学医院的体外受精单元。
三对被诊断为不明原因不孕症并接受体外受精（IVF）治疗的夫妇。
这些夫妇的女性伴侣产生形态正常的卵母细胞，经证明其功能有缺陷，在体外与丈夫和供体精子均无法受精。丈夫的精子对捐赠的卵母细胞进行授精后，所有患者均成功受精，表明丈夫的精液具有正常的受精能力。一名患者在接受卵母细胞捐赠后受孕并分娩。
只有在体外受精和卵母细胞捐赠后，才能确诊卵母细胞缺陷是不孕的原因。
