生殖器疱疹患者中针对单纯疱疹病毒的CD8 + 细胞毒性T淋巴细胞前体的高频率
High frequency of CD8+ cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes.
作者信息
Posavad C M, Koelle D M, Corey L
机构信息
Department of Laboratory Medicine, University of Washington, Seattle 98195, USA.
出版信息
J Virol. 1996 Nov;70(11):8165-8. doi: 10.1128/JVI.70.11.8165-8168.1996.
Abstract
Herpes simplex virus (HSV)-specific CD8+ cytotoxic T lymphocytes (CTL) have rarely been detected in humans, presumably because of virus-induced mechanisms that downregulate major histocompatibility complex class I expression. We have developed a method that has allowed us to consistently demonstrate HSV-specific CD8+ precursor CTL (pCTL) from HSV type 1- and 2-seropositive persons. Major histocompatibility complex-restricted HSV-specific CD8+ pCTL were found in 10 consecutively tested HSV type 1- and 2-seropositive subjects at frequencies ranging from 1 in 21,000 to 1 in 300 (median, 1 in 6,000) versus a pCTL frequency of 1 in 100,000 in HSV-seronegative donors. These results suggest that CD8+ CTL are important effector cells in resolving HSV lesions.
摘要
单纯疱疹病毒（HSV）特异性CD8 + 细胞毒性T淋巴细胞（CTL）在人类中很少被检测到，推测是由于病毒诱导的机制下调了主要组织相容性复合体I类的表达。我们开发了一种方法，使我们能够持续从1型和2型HSV血清阳性个体中检测到HSV特异性CD8 + 前体细胞毒性T淋巴细胞（pCTL）。在连续检测的10名1型和2型HSV血清阳性受试者中发现了主要组织相容性复合体限制的HSV特异性CD8 + pCTL，频率范围为21,000分之一至300分之一（中位数为6,000分之一），而HSV血清阴性供体中的pCTL频率为100,000分之一。这些结果表明，CD8 + CTL是解决HSV损伤的重要效应细胞。
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