英国疟疾常规实验室诊断的准确性。
Accuracy of routine laboratory diagnosis of malaria in the United Kingdom.
作者信息
Milne L M, Kyi M S, Chiodini P L, Warhurst D C
机构信息
Department of Clinical Parasitology, Hospital for Tropical Diseases, London.
出版信息
J Clin Pathol. 1994 Aug;47(8):740-2. doi: 10.1136/jcp.47.8.740.
AIMS
To study the accuracy of routine laboratory diagnosis of malaria with the aim of improving accuracy in diagnosis in the future.
METHODS
A comparative study was made of all blood films submitted to two laboratories in London providing a slide-diagnostic service for malaria.
RESULTS
There were 17 Plasmodium ovale infections, and of these only five (29.4%) were correctly diagnosed by the submitting laboratory; whereas of 210 other single species infections, 162 (77.1%) were correctly diagnosed (chi 2 = 18.4, p < 0.0001). There were six patients with mixed infections; only one (16.7%) was correctly diagnosed, whereas of 227 single species infections, 167 (73.6%) were correctly diagnosed (p = 0.007, using Fisher's exact test). There was no significant association between the presence of technical faults or numerous platelets and incorrect diagnosis.
CONCLUSIONS
Plasmodium ovale and mixed infections were diagnosed incorrectly significantly more often than other species. The presence of technical faults or numerous platelets had no significant effect on whether or not submitting laboratories correctly diagnosed malaria.
目的
研究疟疾常规实验室诊断的准确性，以期未来提高诊断的准确性。
方法
对提交给伦敦两家提供疟疾玻片诊断服务实验室的所有血涂片进行了一项对比研究。
结果
有17例卵形疟原虫感染，其中提交标本的实验室仅正确诊断出5例（29.4%）；而在210例其他单一物种感染中，162例（77.1%）被正确诊断（χ² = 18.4，p < 0.0001）。有6例混合感染患者；仅1例（16.7%）被正确诊断，而在227例单一物种感染中，167例（73.6%）被正确诊断（使用Fisher精确检验，p = 0.007）。技术故障或大量血小板的存在与诊断错误之间无显著关联。
结论
卵形疟原虫和混合感染的误诊率显著高于其他物种。技术故障或大量血小板的存在对提交标本的实验室是否能正确诊断疟疾没有显著影响。
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