• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

库欣综合征与复发性卵巢子宫内膜样腺癌相关。

Cushing's syndrome associated with recurrent endometrioid adenocarcinoma of the ovary.

作者信息

Crawford S M, Pyrah R D, Ismail S M

机构信息

Cancer Medicine Research Unit, University of Bradford, West Yorkshire.

出版信息

J Clin Pathol. 1994 Aug;47(8):766-8. doi: 10.1136/jcp.47.8.766.

DOI:10.1136/jcp.47.8.766
PMID:7962637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC502157/
Abstract

Ectopic production of adrenocorticotrophic hormone (ACTH) by malignant neoplasms is a well recognised cause of Cushing's syndrome but is extremely rare in ovarian carcinoma. A patient who underwent surgery for ovarian carcinoma followed by a course of chemotherapy is reported. The tumour was a bilateral moderately differentiated endometrioid adenocarcinoma and contained numerous chromogranin immunoreactive endocrine cells as well as small foci of ACTH immunoreactivity. She subsequently presented with Cushing's syndrome in association with extensive pelvic recurrence of the tumour.

摘要

恶性肿瘤异位产生促肾上腺皮质激素（ACTH）是库欣综合征的一个公认病因，但在卵巢癌中极为罕见。本文报道了一名接受卵巢癌手术及化疗疗程的患者。肿瘤为双侧中度分化的子宫内膜样腺癌，含有大量嗜铬粒蛋白免疫反应性内分泌细胞以及小灶性ACTH免疫反应性。她随后出现库欣综合征，同时伴有肿瘤广泛的盆腔复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e971/502157/bdb42180e0d7/jclinpath00221-0089-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e971/502157/491c464ae15f/jclinpath00221-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e971/502157/bdb42180e0d7/jclinpath00221-0089-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e971/502157/491c464ae15f/jclinpath00221-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e971/502157/bdb42180e0d7/jclinpath00221-0089-b.jpg

相似文献

1
Cushing's syndrome associated with recurrent endometrioid adenocarcinoma of the ovary.库欣综合征与复发性卵巢子宫内膜样腺癌相关。
J Clin Pathol. 1994 Aug;47(8):766-8. doi: 10.1136/jcp.47.8.766.
2
Cushing's syndrome due to an ACTH-producing primary ovarian carcinoma.因 ACTH 分泌型原发性卵巢癌导致的库欣综合征。
Hormones (Athens). 2014 Jan-Mar;13(1):140-5. doi: 10.1007/BF03401329.
3
Development of Cushing's syndrome during effective chemotherapy for small cell lung cancer.小细胞肺癌有效化疗期间库欣综合征的发生
Intern Med. 2011;50(4):335-8. doi: 10.2169/internalmedicine.50.4127. Epub 2011 Feb 15.
4
Cushing's syndrome secondary to ectopic ACTH secretion from a primary ovarian carcinoma.原发性卵巢癌异位分泌促肾上腺皮质激素导致的库欣综合征。
Clin Endocrinol (Oxf). 1996 Dec;45(6):775-8. doi: 10.1046/j.1365-2265.1996.8670877.x.
5
[Paraneoplastic Cushing's syndrome, a real diagnostic and therapeutic challenge: A case report and literature review].[副肿瘤性库欣综合征：一项真正的诊断和治疗挑战——病例报告及文献综述]
Rev Med Interne. 2015 Dec;36(12):843-7. doi: 10.1016/j.revmed.2014.12.008. Epub 2015 Jan 19.
6
Ectopic ACTH syndrome associated with ovarian steroid-cell tumor.与卵巢类固醇细胞瘤相关的异位促肾上腺皮质激素综合征。
J Endocrinol Invest. 2002 Apr;25(4):369-72. doi: 10.1007/BF03344020.
7
A case report of a patient with bronchial carcinoid tumour and late presentation of Cushing's syndrome.
Ann Acad Med Singap. 1998 Mar;27(2):272-6.
8
Cushing's syndrome due to ovarian serous adenocarcinoma secreting multiple endocrine substances: a case report and immunohistochemical analysis.
Gynecol Oncol. 2003 Sep;90(3):662-6. doi: 10.1016/s0090-8258(03)00407-4.
9
Ectopic Cushing's syndrome in a patient with squamous cell carcinoma of the lung due to CRF-like production.一名因产生类促肾上腺皮质激素释放因子而患肺鳞状细胞癌的患者出现异位库欣综合征。
Monaldi Arch Chest Dis. 1994 Feb;49(1):19-21.
10
Endometrioid carcinoma of the ovary. A clinicopathological study of 17 cases.卵巢子宫内膜样癌。17例临床病理研究。
Eur J Gynaecol Oncol. 1994;15(2):96-100.

引用本文的文献

1
Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK.神经发育障碍与癌症一样，与染色质重塑因子、PI3K/mTOR以及PAK1调节的MAPK功能受损有关。
Biophys Rev. 2023 Apr 1;15(2):163-181. doi: 10.1007/s12551-023-01054-9. eCollection 2023 Apr.
2
Paraneoplastic Cushing's syndrome and hypercalcemia arising from metastatic endometrioid endometrial adenocarcinoma: A case report.副肿瘤性库欣综合征及转移性子宫内膜样腺癌所致高钙血症：一例报告
Gynecol Oncol Rep. 2019 Jun 18;29:58-60. doi: 10.1016/j.gore.2019.06.005. eCollection 2019 Aug.
3
Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case.

本文引用的文献

1
CUSHING'S AND MALIGNANT CARCINOID SYNDROMES FROM OVARIAN NEOPLASM.卵巢肿瘤引起的库欣综合征和恶性类癌综合征。
Arch Intern Med. 1965 Apr;115:490-4. doi: 10.1001/archinte.1965.03860160116021.
2
Cushing's syndrome associated with adenocarcinoma of the ovary.
Lancet. 1958 Nov 8;2(7054):992-4. doi: 10.1016/s0140-6736(58)90479-3.
3
Argyrophil cells in the endometrioid carcinoma of the ovary.
Cancer. 1984 Oct 15;54(8):1569-73. doi: 10.1002/1097-0142(19841015)54:8<1569::aid-cncr2820540817>3.0.co;2-j.
4
因卵巢转移的胰腺神经内分泌肿瘤导致的库欣综合征：1 例临床病理描述。
Endocr Pathol. 2011 Jun;22(2):118-24. doi: 10.1007/s12022-011-9153-z.
4
Ectopic ACTH syndrome associated with ovarian steroid-cell tumor.与卵巢类固醇细胞瘤相关的异位促肾上腺皮质激素综合征。
J Endocrinol Invest. 2002 Apr;25(4):369-72. doi: 10.1007/BF03344020.
Immunohistochemical demonstration of peptide hormones in endometrial carcinomas.
Cancer. 1984 Nov 15;54(10):2127-31. doi: 10.1002/1097-0142(19841115)54:10<2127::aid-cncr2820541012>3.0.co;2-k.
5
Pathology of 'nonendocrine' tumors associated with Cushing's syndrome.与库欣综合征相关的“非内分泌”肿瘤的病理学
Cancer. 1968 Aug;22(2):274-86. doi: 10.1002/1097-0142(196808)22:2<274::aid-cncr2820220204>3.0.co;2-w.
6
Endocrine cells in the female genital tract.
Int J Gynecol Pathol. 1986;5(1):75-87. doi: 10.1097/00004347-198603000-00009.
7
Corticotroph cell pituitary adenoma within an ovarian teratoma. A new cause of Cushing's syndrome.
Am J Surg Pathol. 1987 Mar;11(3):218-24. doi: 10.1097/00000478-198703000-00007.
8
Diagnosis and management of ACTH-dependent Cushing's syndrome: comparison of the features in ectopic and pituitary ACTH production.促肾上腺皮质激素（ACTH）依赖性库欣综合征的诊断与管理：异位和垂体ACTH分泌特征的比较
Clin Endocrinol (Oxf). 1986 Jun;24(6):699-713. doi: 10.1111/j.1365-2265.1986.tb01667.x.
9
Immunocytochemical study of 18 tumours causing ectopic Cushing's syndrome.18例引起异位库欣综合征的肿瘤的免疫细胞化学研究。
J Clin Pathol. 1986 Sep;39(9):955-60. doi: 10.1136/jcp.39.9.955.
10
Cushing's syndrome due to ACTH-production of an ovarian carcinoid.由卵巢类癌产生促肾上腺皮质激素（ACTH）所致的库欣综合征。
Klin Wochenschr. 1989 Jun 15;67(12):640-4. doi: 10.1007/BF01718148.