复发性胰岛素诱导低血糖发作后的脑代谢：一项PET研究。
Brain metabolism after recurrent insulin induced hypoglycaemic episodes: a PET study.
作者信息
Chabriat H, Sachon C, Levasseur M, Grimaldi A, Pappata S, Rougemont D, Masure M C, De Recondo A, Samson Y
机构信息
Service Hospitalier Frédéric Joliot, Dripp, CEA, Orsay, France.
出版信息
J Neurol Neurosurg Psychiatry. 1994 Nov;57(11):1360-5. doi: 10.1136/jnnp.57.11.1360.
Abstract
Neuropsychological testing was carried out and the rate of oxygen metabolism in the brain was measured by PET in 15 highly selected patients with type 1 diabetes. The aim was to investigate the impact on the brain of hypoglycaemic comas resulting from insulin treatment. No significant difference was found between nine patients with a history of more than 10 hypoglycaemic comas and six others who denied any history of such events. These data suggest that intensified insulin treatment, although increasing the frequency of hypoglycaemic coma, may not always be harmful for the brain. This may be explained by the limited duration of hypoglycaemic coma induced by conventional insulin treatment.
摘要
对15例经过严格挑选的1型糖尿病患者进行了神经心理学测试，并通过正电子发射断层扫描（PET）测量了大脑的氧代谢率。目的是研究胰岛素治疗导致的低血糖昏迷对大脑的影响。在9例有10次以上低血糖昏迷病史的患者和另外6例否认有此类事件病史的患者之间未发现显著差异。这些数据表明，强化胰岛素治疗虽然增加了低血糖昏迷的频率，但可能并不总是对大脑有害。这可能是由于传统胰岛素治疗引起的低血糖昏迷持续时间有限所致。
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