Férnandez-Calle P, Jiménez-Jiménez F J, Molina J A, Cabrera-Valdivia F, Vázquez A, García Urra D, Bermejo F, Cruz Matallana M, Codoceo R
Department of Biochemistry, Ciudad Sanitaria La Paz, Spain.
J Neurol Sci. 1993 Aug;118(1):25-8. doi: 10.1016/0022-510x(93)90240-y.
To elucidate the possible role of vitamin C in the risk for developing Parkinson's disease (PD), we compared serum levels of ascorbic acid (vitamin C), measured by a fluorometric method, of 63 PD patients using their spouses as the control group. The serum levels of vitamin C did not differ significantly between the groups (47.13 +/- 0.89 micrograms/ml for PD and 47.60 +/- 0.60 micrograms/ml for controls). There was no influence of antiparkinsonian therapy on vitamin C. Serum levels of vitamin C did not correlate with age, age at onset and duration of the disease, scores of the Unified PD Rating Scale or the Hoehn and Yahr staging in the PD group. These results suggest that serum vitamin C concentrations are apparently unrelated to the risk of developing PD.
为阐明维生素C在帕金森病（PD）发病风险中可能的作用，我们以63例PD患者的配偶作为对照组，采用荧光法比较了两组的血清抗坏血酸（维生素C）水平。两组间维生素C的血清水平无显著差异（PD组为47.13±0.89微克/毫升，对照组为47.60±0.60微克/毫升）。抗帕金森病治疗对维生素C无影响。PD组中，维生素C的血清水平与年龄、发病年龄、病程、统一PD评定量表评分或Hoehn和Yahr分期均无相关性。这些结果表明，血清维生素C浓度显然与PD发病风险无关。
