Hürzeler M B, Einsele F, Leupolz M, Schmitz H J, Strub J R
Department of Prosthodontics, University of Freiburg, Germany.
J Oral Rehabil. 1994 Jul;21(4):373-82. doi: 10.1111/j.1365-2842.1994.tb01152.x.
The aim of this investigation was to evaluate clinically and histologically the use of a synthetic bone graft (Ionogran) alone and in combination with guided bone regeneration (GBR) for alveolar ridge augmentation. Five beagle dogs were used in this study. Prior to the augmentation procedure the maxillary and mandibular second, third and fourth premolars were extracted. Three months after the extractions, impressions from the area of the ridges were taken. Particles of Ionogran were then placed under mucoperiosteal flaps in each quadrant. On the experimental sites, an expanded polytetrafluoroethylene barrier was placed between the flap and the particles. Impressions were retaken at 1 and 3 months after surgery. Three months after surgery, the animals were sacrificed and specimens were prepared for histological evaluation. Computer-assisted volumetric analyses from the casts revealed an increase in ridge volume from baseline in both groups at 1 and 3 months. There was no difference in the height of the augmentation between the test and control sites. The histological results of this study indicate that this new synthetic bone graft appears to be a safe biocompatible grafting material. There were no apparent histological differences between the graft alone and graft/GBR sites. In both groups, however, graft particles were surrounded by dense fibrous connective tissue and bone formation was limited to the graft bone interface.
本研究的目的是从临床和组织学角度评估单独使用合成骨移植材料（Ionogran）以及联合引导骨再生（GBR）技术进行牙槽嵴增高术的效果。本研究使用了5只比格犬。在进行增高手术前，拔除上颌和下颌的第二、第三和第四前磨牙。拔牙3个月后，取牙槽嵴区域的印模。然后将Ionogran颗粒置于每个象限的粘骨膜瓣下。在实验部位，在瓣与颗粒之间放置一个膨化聚四氟乙烯屏障。术后1个月和3个月再次取印模。术后3个月，处死动物并制备标本进行组织学评估。对模型进行计算机辅助体积分析显示，两组在术后1个月和3个月时牙槽嵴体积均较基线增加。试验组和对照组增高的高度没有差异。本研究的组织学结果表明，这种新型合成骨移植材料似乎是一种安全的生物相容性良好的移植材料。单独使用移植材料组和联合GBR组之间在组织学上没有明显差异。然而，在两组中，移植颗粒均被致密的纤维结缔组织包围，骨形成仅限于移植骨界面。
