Plyusnin A, Vapalahti O, Lankinen H, Lehväslaiho H, Apekina N, Myasnikov Y, Kallio-Kokko H, Henttonen H, Lundkvist A, Brummer-Korvenkontio M
Haartman Institute, Department of Virology, Helsinki University, Finland.
J Virol. 1994 Dec;68(12):7833-9. doi: 10.1128/JVI.68.12.7833-7839.1994.
A novel hantavirus has been discovered in European common voles, Microtus arvalis and Microtus rossiaemeridionalis. According to sequencing data for the genomic RNA S segment and nucleocapsid protein and data obtained by immunoblotting with a panel of monoclonal antibodies, the virus, designated Tula virus, is a distinct novel member of the genus Hantavirus. Phylogenetic analyses of Tula virus indicate that it is most closely related to Prospect Hill, Puumala, and Muerto Canyon viruses. The results support the view that the evolution of hantaviruses follows that of their primary carriers. Comparison of strains circulating within a local rodent population revealed a genetic drift via accumulation of base substitutions and deletions or insertions. The Tula virus population from individual animals is represented by quasispecies, indicating the potential for rapid evolution of the agent.
在欧洲普通田鼠（草原田鼠和南俄草原田鼠）中发现了一种新型汉坦病毒。根据基因组RNA S片段和核衣壳蛋白的测序数据以及用一组单克隆抗体进行免疫印迹获得的数据，该病毒被命名为图拉病毒，是汉坦病毒属的一个独特新成员。图拉病毒的系统发育分析表明，它与展望山病毒、普马拉病毒和穆尔托峡谷病毒关系最为密切。这些结果支持了汉坦病毒的进化与其主要宿主的进化一致的观点。对当地啮齿动物种群中传播的毒株进行比较发现，通过碱基替换、缺失或插入的积累会发生基因漂移。来自个体动物的图拉病毒群体由准种代表，这表明该病原体具有快速进化的潜力。
