Chen J, Godschalk M, Katz P G, Mulligan T
Division of Urology, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia.
J Urol. 1995 Jan;153(1):80-1. doi: 10.1097/00005392-199501000-00028.
The recommended dose of prostaglandin E1 as treatment for erectile dysfunction has been reported to be 10 to 40 micrograms. However, adverse effects probably increase with increasing doses. We conducted a prospective, single-blind, dose-escalating study of prostaglandin E1 on 20 men with erectile dysfunction of various etiologies. The response to prostaglandin E1 was assessed by penile palpation and RigiScan rigidity monitoring. A total of 17 patients completed the study: 1 achieved rigidity with 1 microgram., 2 with 2 micrograms. and 4 with 3 micrograms. prostaglandin E1, while more than 70% achieved rigidity with 5 micrograms. or less and more than 80% had a full erection with 20 micrograms. Of 138 injections there were 2 episodes of pain after injection. We conclude that the often recommended starting dose of 20 micrograms. is too high. A more appropriate starting dose is 2.5 micrograms. with increments of 2.5 micrograms. until the lowest effective dose is achieved. This approach may lessen the major impediments to prostaglandin E1 use, that is burning and pain.
据报道，用于治疗勃起功能障碍的前列腺素E1推荐剂量为10至40微克。然而，不良反应可能会随着剂量增加而增多。我们对20名患有各种病因勃起功能障碍的男性进行了一项关于前列腺素E1的前瞻性、单盲、剂量递增研究。通过阴茎触诊和RigiScan硬度监测来评估对前列腺素E1的反应。共有17名患者完成了研究：1名患者使用1微克前列腺素E1达到了硬度，2名使用2微克，4名使用3微克。而超过70%的患者使用5微克或更低剂量达到了硬度，超过80%的患者使用20微克时有完全勃起。在138次注射中，有2次注射后出现疼痛。我们得出结论，通常推荐的20微克起始剂量过高。更合适的起始剂量是2.5微克，每次增加2.5微克，直至达到最低有效剂量。这种方法可能会减少使用前列腺素E1的主要障碍，即烧灼感和疼痛。
