Bah M, Bye R, Pereda-Miranda R
Departamento de Farmacia, Facultad de Quimica, Universidad Nacional Autónoma de México, D.F., México.
J Ethnopharmacol. 1994 Jun;43(1):19-30. doi: 10.1016/0378-8741(94)90112-0.
A study of the hepatotoxic pyrrolizidine alkaloids (PAs) contained in Packera candidissima (Greene) Weber & Löve (Senecio candidissimus Greene), a Mexican medicinal plant used for the treatment of kidney ailments and noted for its antiseptic properties, is reported. Analysis by TLC and GC-MS have shown the presence in high levels of both PAs and their N-oxides in the root (0.76% dry weight) and the aerial parts (0.36% dry weight) of the plant material. GC-MS analysis showed the presence of senecionine, integerrimine, retrorsine, and usaramine in the aerial parts. The root was found to contain senkirkine as the major component. These results indicate that users of this herb are at high risk of poisoning, especially members of certain cultural groups in Northern Mexico and the Hispanic population in the southwestern United States. In addition, two sesquiterpenes, neoadenostylone and epineoadenostylone were identified from the neutral extracts of this plant material. The 6 alpha-angeloyloxy-9-oxo-delta 10(1)-furanoeremophilane is reported for the first time as a natural product.
据报道，对墨西哥药用植物白苞匹菊（Packera candidissima (Greene) Weber & Löve，即Senecio candidissimus Greene）中含有的具有肝毒性的吡咯里西啶生物碱（PAs）进行了一项研究。该植物用于治疗肾脏疾病，并以其抗菌特性而闻名。通过薄层色谱法（TLC）和气相色谱 - 质谱联用（GC - MS）分析表明，在植物材料的根部（干重0.76%）和地上部分（干重0.36%）中均大量存在PAs及其N - 氧化物。GC - MS分析表明地上部分存在千里光碱、全缘千里光碱、倒千里光碱和乌沙胺。发现根部以山梗菜碱为主要成分。这些结果表明，使用这种草药的人中毒风险很高，尤其是墨西哥北部某些文化群体的成员和美国西南部的西班牙裔人群。此外，从该植物材料的中性提取物中鉴定出两种倍半萜，新腺毛草酮和表新腺毛草酮。6α - 当归酰氧基 - 9 - 氧代 - δ10(1) - 呋喃雅槛蓝烷作为天然产物首次被报道。
