天花粉蛋白和苦瓜素对离体大鼠肝细胞的作用。
Effect of trichosanthin and momorcharins on isolated rat hepatocytes.
作者信息
Ng T B, Liu W K, Tsao S W, Yeung H W
机构信息
Department of Biochemistry, Chinese University of Hong Kong, Shatin, N.T.
出版信息
J Ethnopharmacol. 1994 Jul 8;43(2):81-7. doi: 10.1016/0378-8741(94)90007-8.
alpha-Momorcharin, beta-momorcharin and trichosanthin increased the secretion of glutamate-pyruvate transaminase, lactate dehydrogenase and isocitrate dehydrogenase by isolated rat hepatocytes into the culture medium. This hepatotoxic effect of the proteins appeared to be concentration-dependent. The plant proteins induced morphological changes in hepatocytes including increased formation of cytoplasmic blebs and a reduction of microvilli on plasma membrane.
α-苦瓜素、β-苦瓜素和天花粉蛋白可使分离的大鼠肝细胞向培养基中分泌谷氨酸丙酮酸转氨酶、乳酸脱氢酶和异柠檬酸脱氢酶增加。这些蛋白质的肝毒性作用似乎呈浓度依赖性。植物蛋白可诱导肝细胞发生形态学变化，包括细胞质小泡形成增加以及质膜上微绒毛减少。
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