Radice A D, Bugaj B, Fitch D H, Emmons S W
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461.
Mol Gen Genet. 1994 Sep 28;244(6):606-12. doi: 10.1007/BF00282750.
We characterized five transposable elements from fish: one from zebrafish (Brachydanio rerio), one from rainbow trout (Salmo gairdneri), and three from Atlantic salmon (Salmo salar). All are closely similar in structure to the Tc1 transposon of the nematode Caenorhabditis elegans. A comparison of 17 Tc1-like transposons from species representing three phyla (nematodes, arthropods, and chordates) showed that these elements make up a highly conserved transposon family. Most are close to 1.7 kb in length, have inverted terminal repeats, have conserved terminal nucleotides, and each contains a single gene encoding similar polypeptides. The phylogenetic relationships of the transposons were reconstructed from the amino acid sequences of the conceptual proteins and from DNA sequences. The elements are highly diverged and have evidently inhibited the genomes of these diverse species for a long time. To account for the data, it is not necessary to invoke recent horizontal transmission.
一种来自斑马鱼（Brachydanio rerio），一种来自虹鳟鱼（Salmo gairdneri），三种来自大西洋鲑鱼（Salmo salar）。所有这些元件在结构上都与线虫秀丽隐杆线虫（Caenorhabditis elegans）的Tc1转座子非常相似。对来自三个门（线虫、节肢动物和脊索动物）的物种的17种类似Tc1的转座子进行比较表明，这些元件构成了一个高度保守的转座子家族。大多数元件长度接近1.7 kb，具有反向末端重复序列，具有保守的末端核苷酸，并且每个元件都包含一个编码相似多肽的单一基因。转座子的系统发育关系是根据概念性蛋白质的氨基酸序列和DNA序列重建的。这些元件高度分化，并且显然已经在这些不同物种的基因组中长时间受到抑制。为了解释这些数据，没有必要引入近期的水平转移。
