Oge A M, Yazici J, Boyaciyan A, Eryildiz D, Ornek I, Konyalioğlu R, Cengiz S, Okşak O Z, Asar S, Baslo A
Department of Neurology, University of Istanbul, Istanbul Faculty of Medicine, Turkey.
Muscle Nerve. 1994 Dec;17(12):1416-30. doi: 10.1002/mus.880171211.
Electrophysiological findings of 27 males with industrial n-hexane polyneuropathy (HPNP) are presented. The results of needle electromyography and nerve conduction studies were compatible with primarily axonal polyneuropathy with secondary segmental demyelination. Motor conduction velocities were the slowest in distal regions of the nerves. In the proximal nerve segments, which were partly tested by magnetic stimulation of the nerve roots, this slowing was much less pronounced. The reduction in mean motor conduction velocities in the forearm segments of ulnar nerves was more than 30% in comparison to the control group means. This reduction was only 10% in the neck-axilla segments. We think that this finding is a reflection of the distal axonopathy process. Central motor conduction times calculated by transcranial magnetic stimulation and spinal nerve root stimulation were found to be prolonged in HPNP patients, indicating that descending motor pathways are affected in human HPNP.
本文介绍了27例患有工业正己烷多发性神经病（HPNP）男性患者的电生理检查结果。针极肌电图和神经传导研究结果与以轴索性多发性神经病为主并伴有继发性节段性脱髓鞘改变相符。运动传导速度在神经的远端区域最慢。在通过神经根磁刺激部分检测的近端神经节段，这种减慢不太明显。与对照组均值相比，尺神经前臂节段的平均运动传导速度降低超过30%。而在颈-腋节段，这种降低仅为10%。我们认为这一发现反映了远端轴索性病变过程。经颅磁刺激和脊髓神经根刺激计算得出的中枢运动传导时间在HPNP患者中延长，表明人类HPNP患者的下行运动通路受到影响。
