van Ooteghem P, D'Hooghe M B, Vlietinck R, Carton H
Department of Neurology, Catholic University of Leuven, Belgium.
Neuroepidemiology. 1994;13(5):220-5. doi: 10.1159/000110383.
Two hundred twenty patients fulfilling the Poser diagnostic criteria for definite and probable multiple sclerosis (MS) were ascertained in an area of Flanders (Belgium) including the city of Leuven through the general practitioners and the neurologists practicing in the area, through the medical records of the National Center for MS and through the membership list of the MS patient society. Leuven is located at a latitude of 50 degrees 53 N. A prevalence rate of 73.8 per 100,000 [95% confidence limits (95% CI) 58.7-89.0] for men and 101.3 (95% CI 80.4-114.5) for women, and of 87.9 for both sexes (95% CI 76.2-99.4) was found on October 1, 1991. This prevalence rate is not significantly different from rates recently reported for other areas in Europe at the same latitude. The female to male ratio however was only 1.41, which is significantly lower than that in neighboring regions.
通过在比利时法兰德斯地区（包括鲁汶市）执业的全科医生和神经科医生，借助国家多发性硬化症中心的病历以及多发性硬化症患者协会的会员名单，确定了220名符合波泽明确型和可能型多发性硬化症（MS）诊断标准的患者。鲁汶位于北纬50度53分。1991年10月1日，男性患病率为每10万人中73.8例[95%置信区间（95%CI）58.7 - 89.0]，女性患病率为每10万人中101.3例（95%CI 80.4 - 114.5），两性患病率为每10万人中87.9例（95%CI 76.2 - 99.4）。该患病率与近期报道的欧洲同一纬度其他地区的患病率无显著差异。然而，女性与男性的比例仅为1.41，显著低于邻近地区。
