Neurology Clinic, Dr. Lütfi Kindar Kartal Training and Research Hospital, Marmara University Faculty of Medicine, Istanbul, Turkey.
Neuroepidemiology. 2011;37(3-4):231-5. doi: 10.1159/000334316. Epub 2011 Dec 1.
Little information exists on multiple sclerosis (MS) in Turkey. With a door-to-door survey in an urban part of Istanbul, we recently reported a prevalence rate of 101/100,000 population. We therefore investigated three rural areas of Turkey at the same latitude.
The same survey methods were used for total populations of two rural areas (Kandıra and Geyve) near Istanbul, and for half the population of Erbaa, all near 40° north latitude on the Black Sea coast.
In Kandıra, 5 of 8 suspects were diagnosed as having MS among 8,171 screened, resulting in a prevalence rate of 61/100,000. Geyve with 7 MS cases in 17,016 screened had a prevalence of 41/100,000, and Erbaa with 15 MS cases in 28,177 screened one of 53/100,000. Together they showed a prevalence of 51/100,000. Of the 27 patients, 20 were women; 25 had definite and 2 possible MS, the former all with abnormal laboratory findings. Average ages were 30.5 years at onset and 39.1 years at diagnosis. Clinical features and course were typical of European MS.
These findings indicate that Turkey is a high-risk MS area, similar to most regions of Mediterranean Europe, where all recent increases are likely due to (undefined) environmental factors.
土耳其的多发性硬化症（MS）信息较少。我们最近通过伊斯坦布尔市区的逐户调查，报告了 101/100000 的流行率。因此，我们在土耳其的三个农村地区进行了调查。
我们对伊斯坦布尔附近的两个农村地区（坎迪拉和盖维）和黑海沿岸纬度相近的一半人口的埃尔巴进行了同样的调查方法。
在坎迪拉，在 8171 名筛查的疑似病例中，有 5 例被诊断为 MS，流行率为 61/100000。在盖维，17016 名筛查中有 7 例 MS，流行率为 41/100000，埃尔巴在 28177 名筛查中有 15 例 MS，流行率为 53/100000。加起来的流行率为 51/100000。在 27 名患者中，20 名是女性；25 例为明确 MS，2 例为可能 MS，前者均有异常实验室发现。发病年龄平均为 30.5 岁，诊断年龄平均为 39.1 岁。临床特征和病程均为典型的欧洲 MS。
这些发现表明，土耳其是一个多发性硬化症高发地区，与地中海欧洲的大多数地区相似，最近所有的发病率增加可能都归因于（未定义的）环境因素。
