用重组痘苗对小鼠进行抗流感肠道免疫。
Enteric immunization of mice against influenza with recombinant vaccinia.
作者信息
Meitin C A, Bender B S, Small P A
机构信息
Department of Immunology and Medical Microbiology, College of Medicine, University of Florida, Gainesville 32610-0266.
出版信息
Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11187-91. doi: 10.1073/pnas.91.23.11187.
Abstract
Intrajejunal administration to mice of a recombinant vaccinia virus containing the influenza virus hemagglutinin gene induced IgA antibody in nasal, gut, and vaginal secretions. It also induced IgG antibody in serum and cell-mediated immunity. The immunization provided significant protection against an influenza virus challenge. This work suggests that enteric-coated recombinant vaccinia could be an orally administered, inexpensive, multivalent, temperature-stable, safe, and effective vaccine for children that could be particularly useful in developing nations, where multiple injections are not easily administered. Oral administration of vaccines should also reduce children's fear of shots at the doctor's office.
摘要
给小鼠空肠内接种含有流感病毒血凝素基因的重组痘苗病毒，可诱导鼻、肠道和阴道分泌物中的IgA抗体。它还可诱导血清中的IgG抗体和细胞介导的免疫反应。这种免疫接种对流感病毒攻击提供了显著的保护作用。这项研究表明，肠溶衣重组痘苗可能是一种口服的、廉价的、多价的、温度稳定的、安全有效的儿童疫苗，在发展中国家可能特别有用，因为在这些国家不容易进行多次注射。口服疫苗还应能减少儿童对在医生办公室打针的恐惧。
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