Rozas J, Aguadé M
Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138.
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11517-21. doi: 10.1073/pnas.91.24.11517.
The DNA sequences of the ribosomal protein 49 (rp49) region were determined for 34 isochromosomal strains of Drosophila subobscura representing two chromosomal arrangements, the OST and the O3 + 4 gene arrangements, which differ by two overlapping inversions. The data reveal that gene conversion is a mechanism responsible for the transfer of genetic information between naturally occurring inversions of Drosophila. The estimated rate of gene transfer by gene conversion at this region, which is close to an inversion breakpoint, is lower than previous estimates obtained experimentally at the rosy (ry) gene in Drosophila melanogaster. Our data indicate that gene arrangements OST and O3 + 4 are monophyletic and rather old (0.58 and 0.73 million years old, respectively).
测定了代表两种染色体排列（OST和O3 + 4基因排列）的34个果蝇次暗果蝇等染色体菌株的核糖体蛋白49（rp49）区域的DNA序列，这两种排列因两个重叠倒位而不同。数据表明基因转换是负责果蝇自然发生的倒位之间遗传信息转移的一种机制。在这个接近倒位断点的区域，通过基因转换进行基因转移的估计速率低于先前在黑腹果蝇的玫瑰色（ry）基因上通过实验获得的估计值。我们的数据表明基因排列OST和O3 + 4是单系的且相当古老（分别为58万年和73万年）。
