基于核苷酸数据的中性分子进化测试。
A test of neutral molecular evolution based on nucleotide data.
作者信息
Hudson R R, Kreitman M, Aguadé M
出版信息
Genetics. 1987 May;116(1):153-9. doi: 10.1093/genetics/116.1.153.
Abstract
The neutral theory of molecular evolution predicts that regions of the genome that evolve at high rates, as revealed by interspecific DNA sequence comparisons, will also exhibit high levels of polymorphism within species. We present here a conservative statistical test of this prediction based on a constant-rate neutral model. The test requires data from an interspecific comparison of at least two regions of the genome and data on levels of intraspecific polymorphism in the same regions from at least one species. The model is rejected for data from the region encompassing the Adh locus and the 5' flanking sequence of Drosophila melanogaster and Drosophila sechellia. The data depart from the model in a direction that is consistent with the presence of balanced polymorphism in the coding region.
摘要
分子进化的中性理论预测，通过种间DNA序列比较所揭示的，以高速率进化的基因组区域，在物种内也将表现出高水平的多态性。我们在此基于恒定速率中性模型对这一预测进行保守的统计检验。该检验需要来自基因组至少两个区域的种间比较数据，以及来自至少一个物种相同区域的种内多态性水平数据。对于包含黑腹果蝇和塞舌尔果蝇的乙醇脱氢酶（Adh）基因座及5'侧翼序列的区域的数据，该模型被拒绝。数据偏离模型的方向与编码区域存在平衡多态性一致。
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