Jarvik M E, Tashkin D P, Caskey N H, McCarthy W J, Rosenblatt M R
Department of Psychiatry, School of Medicine, UCLA 90024.
Physiol Behav. 1994 Sep;56(3):563-70. doi: 10.1016/0031-9384(94)90302-6.
The influence of mentholated vs. regular cigarettes on selected chemical and topographic parameters was measured in 20 smokers in a pulmonary function laboratory. Half the subjects were black and half were white; half were menthol and half regular smokers. All subjects smoked both types of cigarettes, one on each of 2 days. Compared to regular cigarettes, mentholated cigarettes produced a significantly greater boost in carbon monoxide measured as both blood carboxyhemoglobin and end-expired carbon monoxide, despite the fact that mentholated cigarettes decreased average and total cumulative puff volumes and increased mean puff flow rates of inhaled smoke. These chemical and topographic differences were independent of race. No significant differences in depth of inhalation of the smoke or in the amount of insoluble smoke particulates delivered to or retained in the respiratory tract were noted between the two types of cigarettes. Mentholation of cigarettes may decrease volume of smoke inhaled but appears to increase exposure of smokers to toxic effects of carbon monoxide.
在一个肺功能实验室中，对20名吸烟者测量了薄荷醇香烟与普通香烟对选定化学和地形参数的影响。受试者一半是黑人，一半是白人；一半吸薄荷醇香烟，一半吸普通香烟。所有受试者都吸这两种香烟，在两天中的每一天各吸一种。与普通香烟相比，薄荷醇香烟在以血液中碳氧血红蛋白和呼出终末一氧化碳来衡量的一氧化碳水平上产生了显著更大的提升，尽管薄荷醇香烟降低了平均和总累积吸量，并提高了吸入烟雾的平均吸气流速。这些化学和地形差异与种族无关。两种香烟在吸入烟雾的深度或输送到呼吸道或保留在呼吸道中的不溶性烟雾颗粒量方面没有显著差异。香烟的薄荷醇化可能会减少吸入的烟雾量，但似乎会增加吸烟者接触一氧化碳毒性作用的程度。
