Marsland A L, Manuck S B, Fazzari T V, Stewart C J, Rabin B S
Department of Psychology, University of Pittsburgh, Pennsylvania, USA.
Psychosom Med. 1995 May-Jun;57(3):295-8. doi: 10.1097/00006842-199505000-00012.
To determine the stability of individual differences in cellular immune reactions to acute mental stress, we correlated enumerative and functional lymphocyte responses to an evaluative speech task across two experimental sessions scheduled 2 weeks apart in 30 young men. Relative to pretask baseline measurements, the speech stressor elicited a diminished proliferative response to phytohemagglutinin and concanavalin A, a decrease in circulating CD19 lymphocytes, and an increase in both CD8 and CD56 lymphocytes across the two occasions of testing. Test-retest correlations were significant for the magnitude of change in proliferative response to PHA (r = .50, p < .005) and in numbers of circulating CD8 and CD56 cells (r = .53, and .42, respectively; p's < .02). Concomitant cardiovascular responses also correlated significantly over the two experimental sessions (heart rate: r = .78, p < .0001; systolic and diastolic blood pressure: r = .79 and .48, p < .0001 and .007). These data provide initial evidence that interindividual variability of cellular immune responses to acute psychological stress is moderately reproducible on retesting and may therefore denote a stable dimension of individual differences.
为了确定细胞免疫反应中个体差异对急性精神压力的稳定性，我们在30名年轻男性中，将两次间隔两周安排的实验中，针对一项评估性演讲任务的淋巴细胞计数和功能反应进行了关联分析。相对于任务前的基线测量，演讲应激源在两次测试中均引发了对植物血凝素和刀豆蛋白A的增殖反应减弱、循环CD19淋巴细胞减少以及CD8和CD56淋巴细胞增加。对PHA增殖反应的变化幅度（r = 0.50，p < 0.005）以及循环CD8和CD56细胞数量（分别为r = 0.53和0.42；p值均< 0.02）的重测相关性显著。在两个实验阶段中，伴随的心血管反应也显著相关（心率：r = 0.78，p < 0.0001；收缩压和舒张压：r = 0.79和0.48，p < 0.0001和0.007）。这些数据提供了初步证据，表明细胞免疫反应对急性心理压力的个体间变异性在重新测试时具有适度的可重复性，因此可能表示个体差异的一个稳定维度。
