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[从墨西哥尤卡坦州梅里达腹泻儿童中分离出的G型轮状病毒的频率]

[Frequency of serotype G rotavirus isolated from children with diarrhea in Mérida, Yucatán, Mexico].

作者信息

González-Losa M R, Puerto-Solís M, Polanco-Marín G G, Peniche-Rodríguez R, Puerto F I

机构信息

Departamento de Virología del Centro de Investigaciones Regionales, Universidad Autónoma de Yucatán, Mérida.

出版信息

Rev Invest Clin. 1994 May-Jun;46(3):215-9.

PMID:7973145
Abstract

During a period of six years (1985-1990), rotavirus G serotypes were investigated in 104 fecal samples isolates according to an immune enzyme assay using specific monoclonal antibodies against serotypes 1, 2, 3, and 4 of the VP7. The serotypes were established in 65 samples (62.5%) and could not be determined in 39 samples. In the 65 classified serotypes, 7 (6.7%) were found to belong to serotype 1, 23 (22.1%) to serotype 2, 12 (11.5%) to serotype 3, and 23 (22.1%) to serotype 4. The occurrence of the four serotypes during the six years was: serotype 3 was present in three of the six years; serotype 2 was detected in two epidemic outbreaks (1989 and 1990); serotype 3 appeared in the second year and was seen in the remainder of the study; and serotype 4 was present in the six years. We conclude that the four serotypes occur in our population and that future efforts to test the efficacy of any vaccine against this virus should evaluate a protective response against the four serotypes.

摘要

在六年期间(1985 - 1990年),根据使用针对VP7血清型1、2、3和4的特异性单克隆抗体的免疫酶测定法,对104份粪便样本分离株中的轮状病毒G血清型进行了调查。在65份样本(62.5%)中确定了血清型,39份样本无法确定血清型。在65种分类血清型中,发现7份(6.7%)属于血清型1,23份(22.1%)属于血清型2,12份(11.5%)属于血清型3,23份(22.1%)属于血清型4。这四种血清型在六年期间的出现情况如下:血清型3在六年中的三年出现;血清型2在两次疫情爆发(1989年和1990年)中被检测到;血清型3在第二年出现并在研究的其余时间可见;血清型4在六年中均有出现。我们得出结论,这四种血清型在我们的人群中出现,并且未来测试任何针对该病毒疫苗效力的努力都应评估针对这四种血清型的保护性反应。

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