Aebi C, Schaad U B
Medizinische Universitäts-Kinderklinik, Inselspital Bern.
Schweiz Med Wochenschr. 1994 Oct 22;124(42):1837-40.
Since there is no specific treatment for tick-borne encephalitis (TBE), immunoprophylaxis is used in endemic areas for controlling this disease. Active immunization has been shown to be effective and safe, and a restrictive immunization policy is generally accepted in Switzerland. However, the use of TBE-immunoglobulin for passive immunization after tick exposure is controversial. This article demonstrates that the published reports on the protection rate of TBE-immunoglobulin do not stand up to critical analysis. Efficacy has never been proved. Therefore, the use of TBE-immunoglobulin must be based upon practical or theoretical arguments. Routine administration of this preparation in endemic areas cannot be recommended.
由于目前尚无针对蜱传脑炎（TBE）的特效治疗方法，因此在流行地区采用免疫预防措施来控制这种疾病。主动免疫已被证明是有效且安全的，瑞士普遍接受一种限制性免疫政策。然而，蜱叮咬后使用TBE免疫球蛋白进行被动免疫存在争议。本文表明，已发表的关于TBE免疫球蛋白保护率的报告经不起严格分析。其有效性从未得到证实。因此，TBE免疫球蛋白的使用必须基于实际或理论依据。不建议在流行地区常规使用这种制剂。
