一种针对阿尔茨海默病的潜在非侵入性神经生物学检测方法。

A potential noninvasive neurobiological test for Alzheimer's disease.

作者信息

Scinto L F, Daffner K R, Dressler D, Ransil B I, Rentz D, Weintraub S, Mesulam M, Potter H

机构信息

Laboratory of Eye Movements and Higher Cortical Functions, Brigham and Women's Hospital, MA 02115.

出版信息

Science. 1994 Nov 11;266(5187):1051-4. doi: 10.1126/science.7973660.

DOI:10.1126/science.7973660

PMID:7973660

Abstract

Currently Alzheimer's disease, which affects more than 20 million people worldwide, can only be definitely diagnosed by histological examination of brain tissue obtained at autopsy or biopsy. There is a great need for an early, noninvasive, sensitive, and easily administered diagnostic test of Alzheimer's disease. Here it is reported that patients diagnosed with probable Alzheimer's disease by standard clinical criteria exhibited a marked hypersensitivity in their pupil dilation response to a cholinergic antagonist, tropicamide, placed in their eyes. It was possible to distinguish 18 of 19 individuals (95%) either clinically diagnosed with Alzheimer's disease or classified as suspect Alzheimer's individuals by neuropsychological screening from 30 of 32 normal elderly controls (94%).

摘要

目前，全球有超过2000万人受阿尔茨海默病影响，而该病只能通过尸检或活检获取的脑组织进行组织学检查才能明确诊断。对于阿尔茨海默病，迫切需要一种早期、非侵入性、灵敏且易于实施的诊断测试。据报道，通过标准临床标准诊断为可能患有阿尔茨海默病的患者，在其眼睛滴入胆碱能拮抗剂托吡卡胺后，瞳孔扩张反应表现出明显的超敏反应。通过这种方法，从32名正常老年对照者中的30人（94%）中，有可能区分出19名个体中的18名（95%），这些个体要么临床诊断为患有阿尔茨海默病，要么通过神经心理学筛查被归类为疑似阿尔茨海默病个体。