用肠炎沙门氏菌11RX免疫后小鼠对克雷布斯腹水瘤、肉瘤S180和PC6浆细胞瘤的抵抗力。

Resistance of mice to Krebs ascites tumour, sarcoma S180 and PC6 plasmacytoma after immunisation with Salmonella enteritidis 11RX.

作者信息

Tindle R W, Neoh S H, Ashley M P, Hardy D, Kotlarski I

出版信息

Aust J Exp Biol Med Sci. 1976 Apr;54(2):149-55. doi: 10.1038/icb.1976.15.

DOI:10.1038/icb.1976.15

Abstract

Resistance to Krebs ascites tumour, sarcoma S180 (ascitic form) and PC6 plasmacytoma can be induced with prior immunisation with live Salmonella enteritidis 11RX. One thousand to ten thousand more tumour cells are needed to give an LD50 after immunisation. Resistance to PC6 could be recalled 137 days after intravenous immunisation with 11RX protein antigen intraperitoneally as measured by prolonged survival or monitoring the death of 5[131I]-iodo-2'-deoxyuridine labelled tumour cells in vivo. The range of tumours to which resistance can be produced by 11RX immunisation suggests that the mechanism of resistance does not involve antigens common to the tumours and Salmonella enteritidis 11RX.

摘要

用活的肠炎沙门氏菌11RX预先免疫可诱导对克雷布斯腹水瘤、肉瘤S180（腹水型）和PC6浆细胞瘤产生抗性。免疫后需要多1000至10000个肿瘤细胞才能产生半数致死剂量。静脉注射11RX后137天，通过延长生存期或监测体内5-[131I]-碘-2'-脱氧尿苷标记的肿瘤细胞死亡情况，腹腔注射11RX蛋白抗原可唤起对PC6的抗性。11RX免疫可产生抗性的肿瘤范围表明，抗性机制不涉及肿瘤和肠炎沙门氏菌11RX共有的抗原。