Adair J C, Gold M, Bond R E
Department of Neurology, Shands Hospital, University of Florida, Gainesville 32610.
South Med J. 1994 Dec;87(12):1227-31. doi: 10.1097/00007611-199412000-00006.
Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system. We discuss our observations in the cases of two patients with acyclovir neurotoxicity and review the findings of all previous reports in the English language literature. Systemic disease, most commonly renal dysfunction, preceded all 30 reported cases of acyclovir neurotoxicity. The most common symptoms were mental status disorder and involuntary movements. Measurement of serum acyclovir levels substantiated the diagnosis in only a subset of patients. Although all patients recovered, hemodialysis hastened the rate of recovery.
阿昔洛韦会产生一些神经症状，这些症状类似于病毒感染扩展至中枢神经系统。我们讨论了两例阿昔洛韦神经毒性患者的观察结果，并回顾了英文文献中所有先前报告的研究结果。全身性疾病，最常见的是肾功能不全，在所有30例报告的阿昔洛韦神经毒性病例中均先于发病。最常见的症状是精神状态紊乱和不自主运动。仅在部分患者中，血清阿昔洛韦水平的测定证实了诊断。尽管所有患者均康复，但血液透析加快了康复速度。
