Galli R, Parlapiano M, Pace Napoleone C, Pierangeli A
Cattedra di Chirurgia del Cuore e dei Grossi Vasi, Università degli Studi di Bologna.
Minerva Urol Nefrol. 1994 Jun;46(2):105-11.
Due to the considerable progress made by instrumental total body diagnostics (ECO, CAT, RMN, angiography, etc.) in recent years heart surgery has increasingly often been used to treat pathologies which are not primarily cardiac but which see the involvement of the heart and large vessels in the advanced stages of cancer and non-cancer diseases of other organs or apparatus. This is the case of malignant renal or adrenal tumours which infiltrate along the caval lumen until they reach the right atrium. In these cases caval and atrial involvement must be seen as a prolapse of the tumour and not a long-distance metastasis: prognosis only appears to be linked to the hemodynamic impairment caused by the obstacle to systemic lower venous drainage. On the bases of this observation radical surgery may be justified at a renal, caval and cardiac level. The authors report their preliminary experience in 6 patients with renal cancer (4 renal carcinoma, 1 Wilm's tumour, 1 adrenal carcinoma) who underwent combined surgery, in a single stage, involving enlarged nephrectomny and caval and atrial thrombectomy, the latter performed in profound hypothermia and cardiocirculatory arrest. Two patients died later and 4 are living, in good condition and with perviousness of the lower caval venous drainage. Similar to other analogous experience reported in the literature, the authors suggest taking a combined approach performed in a single stage into consideration for these patients.
近年来,由于仪器全身诊断(超声心动图、计算机断层扫描、磁共振成像、血管造影等)取得了显著进展,心脏手术越来越多地用于治疗并非原发性心脏疾病,但在癌症及其他器官或系统的非癌症疾病晚期累及心脏和大血管的病症。恶性肾肿瘤或肾上腺肿瘤沿腔静脉腔浸润直至到达右心房的情况便是如此。在这些病例中,腔静脉和心房受累应被视为肿瘤的脱垂,而非远距离转移:预后似乎仅与下腔静脉系统引流受阻导致的血流动力学损害有关。基于这一观察结果,在肾脏、腔静脉和心脏层面进行根治性手术可能是合理的。作者报告了6例肾癌患者(4例肾细胞癌、1例威尔姆斯瘤、1例肾上腺癌)的初步经验,这些患者接受了一期联合手术,包括扩大肾切除术以及腔静脉和心房血栓切除术,后者在深度低温和心脏循环骤停下进行。2例患者随后死亡,4例存活,状况良好,下腔静脉引流通畅。与文献中报道的其他类似经验相似,作者建议对这些患者考虑采用一期联合手术方法。