Noel J C, Thiry L, Verhest A, Deschepper N, Peny M O, Sattar A A, Schulman C C, Haot J
Department of Pathology, Erasme University Hospital, Brussels, Belgium.
Urology. 1994 Nov;44(5):671-5. doi: 10.1016/s0090-4295(94)80202-5.
The study evaluated the conflicting results of the role of human papillomavirus (HPV) in the development of bladder carcinoma.
We analyzed the frequency of HPV types 6, 11, 16, 18, and 33 by using polymerase chain reaction on formalin-fixed, paraffin-embedded specimens, from 75 cases of transitional cell carcinoma (TCC) of the bladder. Fifteen samples of normal urothelium adjacent to TCC (10) or from normal bladder obtained at autopsy (5) served as negative controls.
HPV type 16 deoxyribonucleic acid (DNA) was detected in 2 (2.7%) of the 75 cases of TCC and in none of the normal urinary bladder cases. The 2 patients with HPV type 16 were immunosuppressed after undergoing renal and cardiac transplantation.
These results strongly suggest that HPVs play a minor role in the development of TCC of the bladder in the general population, although they can act as oncogenic agents in predisposed patients, such as those who are immunosuppressed.
本研究评估了人乳头瘤病毒（HPV）在膀胱癌发生过程中作用的相互矛盾的结果。
我们采用聚合酶链反应，对75例膀胱移行细胞癌（TCC）福尔马林固定、石蜡包埋标本中的HPV 6、11、16、18和33型的频率进行了分析。15份与TCC相邻的正常尿路上皮样本（10份）或尸检时获得的正常膀胱样本（5份）作为阴性对照。
在75例TCC病例中有2例（2.7%）检测到HPV 16型脱氧核糖核酸（DNA），而正常膀胱病例中均未检测到。2例HPV 16型患者在接受肾和心脏移植后免疫功能受到抑制。
这些结果强烈表明，HPV在普通人群膀胱TCC的发生中起次要作用，尽管它们可在易感患者（如免疫功能受抑制者）中作为致癌因子起作用。
