Noel J C, Peny M O, Mat O, Antoine M, Firket C, Detremmerie O, Thiry L, Verhest A, Vereerstraeten P
Department of Pathology, Erasme Hospital, Free University of Brussels, Belgium.
Transpl Int. 1994 Aug;7(5):340-3. doi: 10.1007/BF00336709.
This report describes two cases of rapidly progressive, multifocal transitional cell carcinomas of the bladder that developed in two patients after renal and cardiac transplantation, respectively. In both cases human papillomavirus (HPV) type 16 DNA was detected using the polymerase chain reaction DNA amplification method. To our knowledge, this HPV type has not been previously described in multifocal bladder transitional cell carcinoma in transplanted patients. Our findings suggest that HPV may play a major role in the development of rapidly progressive, multifocal transitional cell carcinoma in immunosuppressed patients.
本报告描述了两例分别在肾移植和心脏移植后发生于两名患者的膀胱快速进展性多灶性移行细胞癌。在这两例病例中，均使用聚合酶链反应DNA扩增法检测到了16型人乳头瘤病毒（HPV）DNA。据我们所知，此前尚未有关于移植患者多灶性膀胱移行细胞癌中这种HPV类型的描述。我们的研究结果表明，HPV可能在免疫抑制患者快速进展性多灶性移行细胞癌的发生中起主要作用。
