Charneau P, Borman A M, Quillent C, Guétard D, Chamaret S, Cohen J, Rémy G, Montagnier L, Clavel F
CNRS URA 1157, Département Sida et Rétrovirus, Institut Pasteur, Paris, France.
Virology. 1994 Nov 15;205(1):247-53. doi: 10.1006/viro.1994.1640.
We report here the isolation and envelope sequence of a divergent HIV-1 isolate from a French woman with AIDS. This virus, HIV-1VAU, is closely related to the recently described Cameroonian viral isolates HIV-1ANT70 and HIV-1MVP5180, until now designated HIV-1 subtype O. Phylogenetic analysis reveals that the three viruses are equidistant from one another and that their mutual divergence is similar to what has been reported between the more conventional HIV-1 subtypes. Therefore, these three viruses could be included in a new viral group, HIV-1 group O (outgroup), distinct from the cluster of other HIV-1 isolates, which we will refer to as group M (Major group). The HIV-1 group O is currently emerging in western central Africa but its spread in Europe has already started.
我们在此报告从一名患有艾滋病的法国女性身上分离出的一种变异型HIV-1毒株及其包膜序列。这种病毒，即HIV-1VAU，与最近描述的喀麦隆病毒毒株HIV-1ANT70和HIV-1MVP5180密切相关，这两种毒株至今被指定为HIV-1 O亚型。系统发育分析表明，这三种病毒相互间距离相等，它们之间的相互差异与更传统的HIV-1亚型之间所报道的情况相似。因此，这三种病毒可被归入一个新的病毒组，即HIV-1 O组（外围组），与其他HIV-1毒株群不同，我们将后者称为M组（主要组）。HIV-1 O组目前正在中非西部出现，但其在欧洲的传播已经开始。
