Marrakchi S, Kim I, Delaporte E, Briand G, Degand P, Maibach H I, Thomas P
Department of Dermatology B, C. Huriez Hospital, Lille, France.
Acta Derm Venereol. 1994 Jul;74(4):298-301. doi: 10.2340/0001555574298301.
Vitamin A and E blood levels were determined, using a high-performance liquid chromatographic method, in 7 patients with erythrodermic psoriasis or psoriatic acral pustulosis associated or not associated with chronic alcoholism, during and after the acute episode. These vitamins were also studied in 5 patients with psoriasis vulgaris involving more than 80% of the surface body area and associated with chronic alcohol intake and in 17 patients with psoriasis vulgaris involving more than 50% of the skin but without chronic alcoholism. Vitamin A blood levels were reduced in all the patients in the group "erythrodermic psoriasis/psoriatic acral pustulosis", while vitamin E blood levels were below the normal range during the acute psoriatic episode only in the 5 patients having a history of chronic alcohol intake in this group. In the other groups--psoriasis vulgaris with chronic alcoholism and psoriasis vulgaris without heavy alcohol consumption--vitamin A and E blood levels were not reduced. The implication of vitamin E in psoriasis, probably by its antioxidant activity, and its relationship with selenium are discussed. We suggest that attention should be paid to the vitamin A deficiency in erythrodermic or pustular psoriasis and to the vitamin E deficiency when these inflammatory diseases are associated with chronic alcoholism.
采用高效液相色谱法测定了7例红皮病型银屑病或脓疱型银屑病患者在急性发作期及发作后的维生素A和E血水平，这些患者伴有或不伴有慢性酒精中毒。还对5例寻常型银屑病累及体表面积超过80%且伴有慢性酒精摄入的患者以及17例寻常型银屑病累及皮肤超过50%但无慢性酒精中毒的患者进行了这些维生素的研究。在“红皮病型银屑病/脓疱型银屑病”组的所有患者中，维生素A血水平均降低，而仅在该组有慢性酒精摄入史的5例患者中，维生素E血水平在银屑病急性发作期低于正常范围。在其他组——伴有慢性酒精中毒的寻常型银屑病组和无大量酒精摄入的寻常型银屑病组——维生素A和E血水平未降低。讨论了维生素E在银屑病中的作用，可能是通过其抗氧化活性，以及它与硒的关系。我们建议，对于红皮病型或脓疱型银屑病应关注维生素A缺乏，而当这些炎症性疾病与慢性酒精中毒相关时应关注维生素E缺乏。
