寻常型银屑病患者血浆维生素A和E水平及泪膜变化的评估。
Evaluation of plasma vitamin A and E levels and tear film changes in patients with psoriasis vulgaris.
作者信息
Demir Helin Deniz, Aydın Erdinç, Sezer Engin, Yardım Hüseyin
机构信息
Department of Ophthalmology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.
出版信息
Korean J Ophthalmol. 2013 Jun;27(3):158-61. doi: 10.3341/kjo.2013.27.3.158. Epub 2013 Mar 19.
PURPOSE
To evaluate whether alterations in plasma vitamin A and E levels in patients with psoriasis have an effect on tear film changes.
METHODS
Sixty-two eyes of 31 patients with psoriasis vulgaris (Group A) and 74 eyes of 37 age- and gender-matched control subjects (Group B) were included in the study. Ocular and medical histories and dietary habits were obtained from each patient. The tear film break-up time (TBUT), the Schirmer 1 test results and plasma vitamin A and E levels were evaluated.
RESULTS
The mean Schirmer 1 test score was 14.76 ± 6.12 mm/5 min in Group A and 15.69 ± 3.10 mm/5 min in Group B. The mean plasma levels of vitamins A and E in Groups A and B were 1.86 ± 0.62 µmol/L and 1.88 ± 0.65 µmol/L vs. 26.21 ± 5.13 µmol/L and 27.19 ± 8.89 µmol/L, respectively. The Schirmer 1 test results and plasma vitamin A and E levels were not found to be significantly different between the groups (p > 0.05). The mean TBUT was 9.94 ± 6.18 seconds in Group A and 14.47 ± 5.65 seconds in Group B, a significant difference (p < 0.05). No correlation existed between plasma vitamin A and E levels, TBUT or the severity and duration of the disease (p > 0.05).
CONCLUSIONS
Plasma vitamin A and E levels do not seem to be related to tear film changes in patients with psoriasis vulgaris.
目的
评估银屑病患者血浆维生素A和E水平的改变是否对泪膜变化有影响。
方法
本研究纳入了31例寻常型银屑病患者的62只眼（A组）和37例年龄及性别匹配的对照者的74只眼（B组）。获取每位患者的眼部和病史以及饮食习惯。评估泪膜破裂时间（TBUT）、Schirmer 1试验结果以及血浆维生素A和E水平。
结果
A组Schirmer 1试验平均评分为14.76±6.12 mm/5分钟，B组为15.69±3.10 mm/5分钟。A组和B组维生素A和E的平均血浆水平分别为1.86±0.62 μmol/L和1.88±0.65 μmol/L，以及26.21±5.13 μmol/L和27.19±8.89 μmol/L。两组间Schirmer 1试验结果以及血浆维生素A和E水平无显著差异（p>0.05）。A组平均TBUT为9.94±6.18秒，B组为14.47±5.65秒，差异有统计学意义（p<0.05）。血浆维生素A和E水平、TBUT与疾病的严重程度和病程之间无相关性（p>0.05）。
结论
血浆维生素A和E水平似乎与寻常型银屑病患者的泪膜变化无关。
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