Müller N, Voderholzer U, Kurtz G, Straube A
Department of Psychiatry, Klinikum Innenstadt, University of Munich, Germany.
Acta Neurol Scand. 1994 Jun;89(6):429-32. doi: 10.1111/j.1600-0404.1994.tb02661.x.
A family with coincidence of a restless leg syndrome (RLS) in the mother and a Gilles de la Tourette syndrome (GTS) in the son who also shows increased vulnerability to neuroleptic induced akathisia (NIA) is presented. Since these diseases show parallels from a genetic, pathogenetic and clinical point of view, the familiar coincidence is discussed under these aspects with respect to suggested disturbances of the dopamine and the opiate systems in RLS, GTS, and NIA.
本文介绍了一个家庭，母亲患有不宁腿综合征（RLS），儿子患有 Gilles de la Tourette 综合征（GTS），且儿子对神经阻滞剂诱发的静坐不能（NIA）更为敏感。由于这些疾病在遗传、发病机制和临床方面存在相似之处，因此从这些方面讨论了这种家族性巧合，并提及了RLS、GTS和NIA中多巴胺和阿片系统可能存在的紊乱。
