Voderholzer U, Müller N, Haag C, Riemann D, Straube A
Albert-Ludwigs-University Freiburg, Department of Psychiatry, Germany.
J Neurol. 1997 Aug;244(8):521-6. doi: 10.1007/s004150050136.
Gilles de la Tourette's syndrome (GTS) and restless legs syndrome (RLS) are two different neurological disorders with common features such as involuntary movements. In both disorders a disturbance of the dopaminergic system has been considered among other possible mechanisms. Since periodic leg movements (PLMS) during sleep are the predominant objective finding in RLS, the aim of this study was to investigate sleep parameters in GTS patients with particular emphasis on PLMS. Seven drug-free patients with GTS and seven age- and sex-matched healthy controls were studied polysomnographically, including superficial electromyogram (EMG) leads on all four extremities. A high number of PLMS were found in five of seven, and periodic arm movements in four of seven GTS patients. Total sleep time was significantly lower (P < 0.05) in the GTS patients than in the controls, which confirms earlier findings. The presence of PLMS in GTS might point towards evidence for a pathophysiological relationship between GTS and RLS, which, however, is not supported by the different responses to pharmacological treatments.
抽动秽语综合征（GTS）和不宁腿综合征（RLS）是两种不同的神经系统疾病，具有诸如不自主运动等共同特征。在这两种疾病中，除其他可能机制外，多巴胺能系统紊乱也被考虑在内。由于睡眠期间的周期性腿部运动（PLMS）是不宁腿综合征的主要客观表现，本研究的目的是调查GTS患者的睡眠参数，特别关注PLMS。对7名未用药的GTS患者和7名年龄及性别匹配的健康对照者进行了多导睡眠图检查，包括四肢的表面肌电图（EMG）导联。在7名GTS患者中，有5名发现大量PLMS，7名中有4名出现周期性手臂运动。GTS患者的总睡眠时间显著低于对照组（P < 0.05），这证实了早期的研究结果。GTS中PLMS的存在可能表明GTS与RLS之间存在病理生理关系的证据，然而，这并不得到药理学治疗不同反应的支持。
